Glucosamine hydrochloride, also called glucosamine HCl, is a supplement that comes in several forms and is sometimes combined with ingredients such as shark cartilage or chondroitin sulfate.
People take glucosamine hydrochloride by mouth for osteoarthritis, rheumatoid arthritis, glaucoma, a jaw disorder called temporomandibular disorder (TMD), joint pain,back pain, and weight loss.
Glucosamine hydrochloride is applied to the skin in combination with chondroitin sulfate, shark cartilage, and camphor for osteoarthritis.
Glucosamine hydrochloride is used parenterally and short-term to reduce osteoarthritis symptoms.
Glucosamine in the body is used to make a “cushion” that surrounds the joints. In osteoarthritis, this cushion becomes thinner and stiff. Taking glucosamine hydrochloride as a supplement might help to supply the materials needed to rebuild the cushion.
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking glucosamine hydrochloride if you are pregnant or breast feeding. Stay on the safe side and avoid use.
Asthma: Glucosamine hydrochloride might make asthma worse. If you have asthma, use caution with glucosamine hydrochloride.
Diabetes: Some preliminary research suggests that glucosamine might raise blood sugar in people with diabetes. However, more reliable research indicates that glucosamine does not seem to significantly affect blood sugar control in people with type 2 diabetes. Glucosamine with routine blood sugar monitoring appears to be safe for most people with diabetes.
High cholesterol: There is some concern that glucosamine might cause cholesterol levels to increase in some people. Glucosamine might increase insulin levels. High insulin levels are associated with increased cholesterol levels. However, this effect has not been reported in humans. To be on the safe side, use glucosamine cautiously if you have high cholesterol levels.
High blood pressure: There is some concern that glucosamine might cause blood pressure to increase in some people. Glucosamine might increase insulin levels. High insulin levels are associated with increased blood pressure. However, this effect has not been reported in humans. To be on the safe side, use glucosamine cautiously if you have high blood pressure.
Shellfish allergy: There is some concern that glucosamine products might cause allergic reactions in people who are sensitive to shellfish. Glucosamine is produced from the shells of shrimp, lobster, and crabs. However, allergic reactions in people with shellfish allergy are caused by the meat of shellfish, not the shell. There are no reports of allergic reactions to glucosamine in people who are allergic to shellfish. There is also some information that people with shellfish allergy can safely take glucosamine products.
Surgery: Glucosamine hydrochloride might affect blood sugar levels and might interfere with blood sugar control during and after surgery. Stop using glucosamine hydrochloride at least 2 weeks before a scheduled surgery.
Warfarin (Coumadin) interacts with GLUCOSAMINE HYDROCHLORIDE
Warfarin (Coumadin) is used to slow blood clotting. There are several reports showing that taking glucosamine with or without chondroitin increase the effect of warfarin (Coumadin) on blood clotting. This can cause bruising and bleeding that can be serious. Don’t take glucosamine if you are taking warfarin (Coumadin).
Medications for cancer (Antimitotic chemotherapy) interacts with GLUCOSAMINE HYDROCHLORIDE
Some medications for cancer work by decreasing how fast cancer cells can copy themselves. Some scientists think that glucosamine might increase how fast tumor cells can copy themselves. Taking glucosamine along with some medications for cancer might decrease the effectiveness of these medications.
Acetaminophen (Tylenol, others) interacts with GLUCOSAMINE HYDROCHLORIDE
There is some concern that taking glucosamine hydrochloride and acetaminophen (Tylenol, others) together might alter how well each works. But more information is needed to know if this interaction is a big concern.
Medications for diabetes (Antidiabetes drugs) interacts with GLUCOSAMINE HYDROCHLORIDE
There has been concern that glucosamine hydrochloride might increase blood sugar in people with diabetes. There was also the concern that glucosamine hydrochloride might decrease how well medications used for diabetes work. However, research now indicates that glucosamine hydrochloride probably does not increase blood sugar in people with diabetes. Therefore, glucosamine hydrochloride probably does not interfere with diabetes medications. To be cautious, if you take glucosamine hydrochloride and have diabetes, monitor your blood sugar closely.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
2-amino-2-deoxyglucose hydrochloride, 2-Amino-1-Deoxy-Beta-D-Glucopyranose, 2-Amino-2-Deoxy-Beta-D-Glucopyranose Hydrochloride, Amino Monosaccharide, Chitosamine, Chlorhidrato de Glucosamina, Chlorhydrate de Glucosamine, D-Glucosamine HCl, Glucosamine, Glucosamine HCl, Glucosamine KCl, Glucosamine-6-Phosphate
Source: WebMD, http://www.webmd.com/vitamins-supplements/ingredientmono-747-glucosamine%20hydrochloride.aspx?activeingredientid=747&activeingredientname=glucosamine%20hydrochloride