Moderate Interaction Be cautious with this combination:

  • Aluminum interacts with VITAMIN C (ASCORBIC ACID): Aluminum is found in most antacids. Vitamin C can increase how much aluminum the body absorbs. But it isn’t clear if this interaction is a big concern. Take vitamin C two hours before or four hours after antacids.
  • Estrogens interacts with VITAMIN C (ASCORBIC ACID): The body breaks down [[estrogen[[s to get rid of them. Vitamin C might decrease how quickly the body gets rid of estrogens. Taking vitamin C along with estrogens might increase the effects and side effects of estrogens.
  • Fluphenazine (Prolixin) interacts with VITAMIN C (ASCORBIC ACID): Large amounts of vitamin C might decrease how much fluphenazine (Prolixin) is in the body. Taking vitamin C along with fluphenazine (Prolixin) might decrease the effectiveness of fluphenazine (Prolixin).
  • Medications for cancer (Chemotherapy) interacts with VITAMIN C (ASCORBIC ACID): Vitamin C is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. But it is too soon to know if this interaction occurs.
  • Medications used for HIV/AIDS (Protease Inhibitors) interacts with VITAMIN C (ASCORBIC ACID): Taking large doses of vitamin C might reduce how much of some medications used for HIV/AIDS stays in the body. This could decrease the effectiveness of some medications used for HIV/AIDS.
    • Some of these medications used for HIV/AIDS include amprenavir (Agenerase), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase).
  • Medications used for lowering cholesterol (Statins) interacts with VITAMIN C (ASCORBIC ACID): Taking vitamin C, beta-carotene, selenium, and vitamin E together might decrease the effectiveness of some medications used for lowering cholesterol. It is not known if vitamin C alone decreases the effectiveness of some medications used for lowering cholesterol. Some medications used for lowering cholesterol include atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), and pravastatin (Pravachol).
  • Warfarin (Coumadin) interacts with VITAMIN C (ASCORBIC ACID): Warfarin (Coumadin) is used to slow blood clotting. Large amounts of vitamin C might decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Minor Interaction Be watchful with this combination:

  • Acetaminophen (Tylenol, others) interacts with VITAMIN C (ASCORBIC ACID): The body breaks down acetaminophen (Tylenol, others) to get rid of it. Large amounts of vitamin C can decrease how quickly the body breaks down acetaminophen. It is not clear exactly when or if this interaction is a big concern.
  • Aspirin interacts with VITAMIN C (ASCORBIC ACID): The body breaks down aspirin to get rid of it. Large amounts of vitamin C might decrease the breakdown of aspirin. Decreasing the breakdown of aspirin might increase the effects and side effects of aspirin. Do not take large amounts of vitamin C if you take large amounts of aspirin.
  • Choline Magnesium Trisalicylate (Trilisate) interacts with VITAMIN C (ASCORBIC ACID): Vitamin C might decrease how quickly the body gets rid of choline magnesium trisalicylate (Trilisate). But it is not clear if this interaction is a big concern.
  • Nicardipine (Cardene) interacts with VITAMIN C (ASCORBIC ACID): Vitamin C is taken up by cells. Taking nicardipine (Cardene) along with vitamin C might decrease how much vitamin C is taken in by cells. The significance of this interaction is not clear.
  • Nifedipine interacts with VITAMIN C (ASCORBIC ACID): Vitamin C is taken up by cells. Taking nifedipine (Adalat, Procardia) along with vitamin C] might decrease how much vitamin C is taken in by cells. The significance of this interaction is not clear.
  • Salsalate (Disalcid) interacts with VITAMIN C (ASCORBIC ACID): Vitamin C] might decrease how quickly the body gets rid of salsalate (Disalcid). Taking vitamin C along with salsalate (Disalcid) might cause too much salsalate (Disalcid) in the body, and increase the effects and side effects of salsalate.

References

Source: WebMD , www.webmd.com/diet/features/the-benefits-of-vitamin-c
Source: WebMD , www.webmd.com/vitamins-supplements/

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