L-Histidine is an amino acid. People use histidine for medical purposes.



  • Rheumatoid arthritis
  • Anemia associated with kidney failure or kidney dialysis
  • Allergic diseases
  • Ulcers


  • Antifungal properties: A team of Swedish researchers conducted both in-vitro and animal studies on the antifungal properties of histidine-rich glycoprotein, a multimodular plasma protein that is abundant in the human body. When the glycoprotein was added in-vitro to cells of Candida albicans, the histidine-rich protein bound itself to the fungal cells and caused a breakdown in cell walls, eventually destroying the fungus.
  • L-histidine is the chemical precursor to histamines, which play a central role in allergic reactions – the body’s response to the presence of substances it perceives as alien and potentially dangerous. Released in allergic reactions, those histamines set into a motion a series of physical changes, causing the dilation of capillaries, a drop in blood pressure, increased secretion of gastric acids, subcutaneous fluid leakage resulting in itchy skin and hives, and tightening of the smooth muscles of the bronchial tubes.
  •  A deficiency of L-histidine can lead to anemia. Other symptoms of histidine deficiency include scaly dry skin and fatigue
  • Histidine is involved in a wide range of metabolic processes in the body.
    • Functioning as a precursor to histamine
    • Sexual arousal and orgasmic function
    • Rheumatoid Arthritis
    • Precursor to Carnosine and Anserine
    • Gastric acid secretions to aid digestion
    • Circadian rhythms
    • Neuronal health and function
    • Production of red and white blood cells


  •  Not enough is known about the use of histidine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
  • Folic acid deficiency: If you have this condition, don’t use histidine. It can cause an unwanted chemical called formiminoglutamic acid (FIGLU) to build up in the body.


We currently have no information for l-histidine Interactions. Please consult with your doctor.

Other Names

B-Alanyl-L-Histidine, B-Alanyl Histidine, Beta-alanyl-L-histidine, Beta-Alanyl-L-Histidine, Carnosina, L-Carnosine, N-Acetyl-Carnosine, N-Acetyl-Carnosine, N-Acetyl-L-Carnosine, N-Acetyl-L-Carnosine


Source: WebMD, http://www.webmd.com/vitamins-supplements/ingredientmono-467-histidine.aspx?activeingredientid=467&activeingredientname=histidine

Live Strong, http://www.livestrong.com/article/527035-l-histidine-benefits/



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