Nexrutine® Phellodendron Extract

The bark of the tree is an important herbal medicine in China.

Contents

• Uses
• Benefits
• Cautions
• Interactions
• Other names
• References

Uses

• Nexrutine (bark extract from Phellodendron amurense) may have potential to prevent prostate tumor development

Benefits

• Weight loss. Some research suggests that overweight women who take a specific product containing a combination of extracts of phellodendron plus magnolia (Relora, Next Pharmaceuticals) for 6 weeks have less weight gain than other women who did not receive the product. Women taking this product also seem to eat fewer calories than the control group. One possible explanation is that this product reduced stress and stress-related eating. But that theory doesn’t stand up, because so far there is no evidence that this product reduces the stress hormone called cortisol.
• Psoriasis. There is a report that an ointment containing phellodendron plus isatis and Baikal skullcap improved psoriasis in an 8-year-old boy with psoriasis that responded poorly to other treatments.
• Diarrhea.
• Ulcers.
• Osteoarthritis.
• Obesity.
• Diabetes.
• Meningitis.
• Pneumonia.
• Eye infections.
• Tuberculosis.

Cautions

Pregnancy and breast-feeding: It is unsafe to use this product during pregnancy.

Interactions

• Cyclosporine (Neoral, Sandimmune) interacts with PHELLODENDRON
  The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Phellodendron might decrease how fast the body breaks down cyclosporine (Neoral, Sandimmune). Taking phellodendron along with cyclosporine (Neoral, Sandimmune) might increase the chance of side effects.
• Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with PHELLODENDRON
  Some medications are changed and broken down by the liver.
  Phellodendron might decrease how quickly the liver breaks down some medications. Taking phellodendron along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking phellodendron, talk to your healthcare provider if you are taking any medications that are changed by the liver.
  Some medications changed by the liver include cyclosporine (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others.

Other names

Amur Cork Bark, Amur Cork Tree, Amur Corktree, Arbre à Liège de l’Amour, Arbre au Liège de l’Amour, Arbre de Liège de Chine, Corktree, Cortex Phellodendri, Huang Bai, Huang Bo, Phellodendri Cortex, Phellodendron, Phellodendron amurense, Phellodendron de l’Amour.

References

Source:WebMD, http://www.webmd.com/vitamins-supplements/ingredientmono-1095-phellodendron.aspx?activeingredientid=1095&activeingredientname=phellodendron

Wikipedia, https://en.wikipedia.org/wiki/Phellodendron_amurense