Sodium Monofluorophosphate, commonly abbreviated MFP, is an inorganic compound with the chemical formula Na2PO3F.



  • MFP is best known as an ingredient in some toothpastes. It functions as a source of fluoride via the following hydrolysis reaction

    Fluoride protects tooth enamel from attack by bacteria that cause dental caries (cavities). Although developed by a chemist at Procter and Gamble, its use in toothpaste (Colgate toothpaste) was patented by Colgate-Palmolive, as Procter and Gamble was engaged in the marketing of Crest toothpaste (containing stannous fluoride, marketed as “Fluoristan”). In the early 1980s, Crest was reformulated to use MFP, under the trademark “Fluoristat”; today Crest toothpastes use sodium fluoride.

    MFP is also used in some medications for the treatment of osteoporosis.


  • When formulated correctly and used as directed, fluoride toothpaste will help to safely and effectively prevent tooth decay. Numerous clinical studies have demonstrated fluoride’s effectiveness in reducing cavities. Fluoride helps diminish demineralization of tooth enamel and even enhances the remineralization of potential decay spots.


  • The usual content of MFP in toothpaste is 0.76%. The compound is used in place of sodium fluoride because it is less acutely toxic, although both have modest toxicities. The LD50 in rats is 0.9 g/kg. The salt exhibits limited musculoskeletal and respiratory toxicities.



Other names



Source: Wikipedia,


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