Isoleucine (abbreviated as Ile or I) encoded by the codons AUU, AUC, and AUA is an α-amino acid that is used in the biosynthesis of proteins.



  • Isoleucine is found in especially high amounts in meats, fish, cheese, most seeds and nuts, eggs, chickens and lentils.
  • In the human body Isoleucine is concentrated in the muscle tissues.
  • It is necessary for hemoglobin formation and in stabilizing and regulating blood sugar and energy levels. A deficiency of isoleucine can produce symptoms similar to those of hypoglycemia.


  • It is one of several essential amino acids needed in the diet; human beings cannot synthesize it from simpler metabolites. Young adults need about 20 mg of this amino acid per day per kg (or about 8 mg per lb) of body weight. Isoleucine can be degraded into simpler compounds by the enzymes of the body.
  • It is used in the body to produce certain biochemical compounds that help in energy production and has been found experimentally to reduce twitching and tremors in animals. The branched-chain amino acids (BCAA)?isoleucine, leucine, and valine?have been used as supplements for body (muscle) building.
  • Both aerobic exercise and strength training increase protein requirements although they do so for different reasons. During aerobic exercise, AAs can be used for energy production (especially the branch-chain AA’s, leucine, isoleucine, and valine) and may provide up to 10% of the total energy produced during long-duration activity.


Both a deficiency and an overdose can result in negative side effects.


Unknown, please consult with your doctor.

Other names

2-Amino-3-methylpentanoic acid


Source: Wikipedia,




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